Oral Corticosteroids did not Prevent AGEP due to Terbinafine

Oral corticosteroids did not prevent AGEP due to terbinafine.

Sir, Terbinafine is the most common antimycotic agent that can result in acute generalized exanthematous pustulosis (AGEP). The clinical features, laboratory findings and histopathology of AGEP are now well described. How­ ever the optimum management of this condition has not been agreed. We read with interest the recent case described by Beltraminelli et al. (1) and would like to report a furt...

Allergic Maculo-Papular Exanthema Due To Terbinafine

We report on a 76-year-old male patient who developed a maculopapular generalised exanthema due to terbinafine. Prick test was negative; patch test revealed a positive reaction after 48 h confirming the delayed-type allergic reaction. Non-pustular exanthema has only rarely been reported for terbinafine.

Corticosteroids do not prevent optic nerve atrophy following optic neuritis.

Corticosteroids shorten the period of functional impairment following relapses in optic neuritis and multiple sclerosis (MS); however they have not, thus far, been shown to affect the final level of function compared with placebo. There has been recent interest in the use of corticosteroids as neuroprotective agents by their effect of decreasing nitric oxide (NO) production by mononuclear cells...

Calcium did not prevent fractures in elderly women.

Homocysteine-lowering therapy did not prevent stroke recurrence.

P a t i e n t s 3680 patients who were ≥ 35 years of age (mean age 66 y, 63% men) and had nondisabling ischemic stroke and elevated total homocysteine (tHcy) levels. Exclusion criteria included embolic stroke, other major neurologic illness, life expectancy < 2 years, need for dialysis, and untreated anemia or vitamin B12 deficiency. Follow-up was 92%. I n t e r v e n t i o n Patients were allo...